Our Research
Chirality: A Fundamental Property of Nature
Chirality refers to the non-superimposability of an object with its mirror image, a pervasive phenomenon in nature with far-reaching implications for human health, chemical industry, life sciences and materials science. Over half of clinical drugs are chiral drugs. A famous case is the thalidomide tragedy: (R)-thalidomide has sedative effects while (S)-thalidomide causes teratogenicity. Our group focuses on the construction of privileged chiral skeletons—the core scientific problem of this field.
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Our Research
Overview: Axially Chiral Chemistry
Axially chiral compounds, whose chirality originates from the highly sterically hindered rotation along a chiral axis, are widespread in biologically active compounds and serve as valuable chiral ligands in asymmetric catalysis. Our group focuses on axial chirality chemistry, systematically developing privileged skeleton construction, novel arene chemistry, and new organocatalytic asymmetric transformations.
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Our Research
Systematic Construction and Application of Axial Chirality
Three synergistic modules: developing novel arene chemistry, creating new axially chiral skeletons, and expanding asymmetric catalysis applications. Our systematic studies have been published as research accounts in Accounts of Chemical Research (2018, 51, 534; 2022, 55, 2920).
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Our Research
Systematic Construction and Development of Axially Chiral Skeletons
Privileged skeletons: NOBIN, BINAM, aryl-naphthols/amines, N-aryl pyrroles, QUINOL N-oxides, QUINAP, etc. Novel skeletons: catalytic asymmetric construction of new axial chirality based on aryl-alkenes, 1,3-dienes, cyclohexadienes, and aryl-boron frameworks.
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Tan Group
The Tan Group at the Department of Chemistry, SUSTech, focuses on organocatalytic axial chirality chemistry. As corresponding author, the group has published 140+ papers in Science, Nature, Nature Chemistry and other leading journals.
Department of Chemistry, Southern University of Science and Technology
140+
发表论文
3
Science/Nature
18
Nat. 系列子刊
88
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